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Andrew Heath

Andrew Heath, Tutor

Spenser T. Olin Professor of Psychiatry (Wash U) and Adjunct Professor of Psychological Sciences (MU)
Washington University School of Medicine, St. Louis
314-286-2203
AHeath@WUSTL.EDU

Research area(s):

  • Behavioral and psychiatric genetics, genetic epidemiology, particularly focusing on the interplay of genetic and environmental risk factors in the etiology of substance use disorder, of affective disorders, and of personality and personality disorders
  •  Prospective high-risk studies of adolescent twins/siblings and their families, and of twin pairs and their adolescent offspring
  • Formulation of models, development and implementation of methods of data analysis, and data collection to resolve the joint contributions of genetic and environmental risk factors, and their covariation and interaction, to risk of psychiatric disorder, and to behavioral variation
  • Dissection of genetic and non-genetic causes for the familial aggregation of risk
     

Publications:

Agrawal, A., Grant, J. D., Littlefield, A. K.*, Waldron, M., Pergadia, M. L., Lynskey, M. T., Madden, P. A. F. , Todorov, A., Trull, T., Bucholz, K. K., Todd, R. D., Sher, K. J. & Heath,  A. C. (2009) Developing a quantitative measure of alcohol consumption for genomic studies on prospective cohorts. Journal of Studies on Alcohol and Drugs, 70, 157-168.

Agrawal, A., Lynskey, M. T., Todorov, A. A., Schrage, A. A., Littlefield, A. K.*, Grant, J. D., Zhu, Q., Nelson, E. C., Madden, P. A. F., Bucholz, K. K., Sher, K. J. & Heath, A. C. (2011). A candidate gene association study of alcohol consumption in young women. Journal of Studies on Alcohol and Drugs, 35, 550-558.

Agrawal, A., Sartor, C. E., Lynskey, M. T., Grant, J. D., Pergadia, M. L., Grucza, R., Bucholz, K. K., Nelson, E. C., Madden, P. A. F., Martin, N. G., & Heath, A. C. (2009). Evidence for an interaction between age at first drink and genetic influences on DSM-IV alcohol dependence symptoms. Alcoholism: Clinical and Experimental Research, 33, 2047-56. PMID: 19764935. PMCID: PMC2883563.

Grant, J. D., Agrawal, A., Bucholz, K. K., Madden, P. A., Pergadia, M. L., Nelson, E. C., Lynskey, M. T., Todd, R. D., Todorov, A. A., Hansell, N. K., Whitfield, J. B., Martin, N. G., & Heath, A. C. (2009). Alcohol consumption indices of genetic risk for alcohol dependence. Biological Psychiatry, 66, 795-800. PMID: 19576574. (NIHMS129858)

Heath, A. C., Whitfield, J. B., Martin, N. G., Pergadia, M. L., Goate, A. M., Lind, P. A., McEvoy, B. P., Schrage, A. J., Grant, J. D., Chou, Y. L., Zhu, R., Henders, A. K., Medland, S. E., Gordon, S. D., Nelson, E. C., Agrawal, A., Nyholt, D. R., Bucholz, K. K., Madden, P. A. F., Montgomery, G. W. (in press). A quantitative-trait genome-wide association study of alcoholism risk in the community: findings and implications. Biological Psychiatry.

 Knopik, V. S., Heath, A. C., Bucholz, K. K., Madden, P. A., & Waldron, M. (2009). Genetic and environmental influences on externalizing behavior and alcohol problems in adolescence: A female twin study. Pharmacology, Biochemistry, and Behavior, 93, 313-321. PMID: 19341765. PMCID: PMC2758781.

Kristjansson, S. D., Agrawal, A., Littlefield, A. K.*, Pergadia, M. L., Lessov-Schlaggar, C. N., Sartor, C. E., Bucholz, K. K., Madden, P. A., Cooper, M. L., Sher, K. J., & Heath, A. C. (2011). Drinking motives in female smokers: factor structure, alcohol dependence, and genetic influences. Alcoholism: Clinical and Experimental Research, 35, 345-54. PMID: 21083669

Littlefield, A. K.*, Agrawal, A., Ellingson, J. M.*, Kristjansson, S., Madden, P. A. F., Bucholz, K. K., Slutske, W. S., Heath, A. C., & Sher, K. J. (in press). Does variance in drinking motives explain the genetic overlap between personality and alcohol use disorder symptoms? A twin study of young women. Alcoholism: Clinical and Experimental Research.

Meier, M. H.*, Slutske, W. S., Heath, A. C., & Martin, N. G. (2011). Sex differences in the genetic and environmental influences on childhood conduct disorder and adult antisocial behavior. Journal of Abnormal Psychology, 120, 377-388. PMID: 21319923

Nelson, E. C., Agrawal, A., Pergadia, M. L., Wang, J. C., Whitfield, J. B., Saccone, F. S., Kern, J., Grant, J. D., Schrage, A. J., Rice, J. P., Montgomery, G. W., Heath, A. C., Goate, A. M., Martin, N. G., & Madden, P. A. (2009). H2 haplotype at chromosome 17q21.31 protects against childhood sexual abuse-associated risk for alcohol consumption and dependence. Addiction Biology, 15, 1-11. PMID: 19878140 (NIHMS 278335)

Park, A., Sher, K., Todorov, A., & Heath, A. C. (in press). Interaction between the DRD4 VNTR polymorphism and proximal and distal environments in alcohol dependence during emerging and young adulthood. Journal of Abnormal Psychology. PMID: 21381802

Piasecki, T. M., Jahng, S., Wood, P. K., Robertson, B. M.*, Epler, A. J.*, Cronk, N. J., Rohrbaugh, J. W., Heath, A. C., Shiffman, S., & Sher, K. J. (in press). The subjective effects of alcohol-tobacco co-use: An ecological momentary assessment investigation. Journal of Abnormal Psychology. PMID: 21443289.

Sartor, C. E., McCutcheon, V. V., Pommer, N. E., Nelson, E. C., Grant, J. D., Duncan, A. E., Waldron, M., Bucholz, K. K., Madden, P. A., & Heath, A. C. (2010). Common genetic and environmental contributions to post-traumatic stress disorder and alcohol dependence in young women. Psychological Medicine, Nov 8 [Epub ahead of print]. PMID: 21054919

Turnbaugh, P. J., Hamady, M., Yatsuneko, T., Cantarel, B. L., Duncan, A. E., Ley, R. E., Sogin, M. L., Jones, W. J., Roe, B. A., Affourtit, J. P., Egholm, M., Henrissat, B., Heath, A. C., Knight, R., & Gordon, J. I. (2009). A core gut microbiome in obese and lean twins. Nature, 457, 480-484. PMID: 19043404. PMCID: PMC2677729.

Yang, J., Benyamin, B., McEvoy, B. P., Gordon, S., Henders, A. K., Nyholt, D., Madden, P. A. F., Heath, A. C., Martin, N. G., Montgomery, G. W., Goddard, M. E., Visscher, P. M. (2010). Common SNPs explain a large proportion of the heritability for human height. Nature Genetics, 42, 565-569. PMID: 20562875

2009 Curators of the University of Missouri. DMCA and other copyright information. An equal opportunity/affirmative action institution.

For more information about the program, e-mail alcoholstudies@missouri.edu.